刘宇博，教授，博士生导师，入选国家级青年人才项目，兴辽英才“青年拔尖”项目，主要研究方向为糖生物学和糖化学生物学。

糖链是继核酸、蛋白质之后的“第三条生命之链”，与癌症等重大疾病发生发展息息相关。针对生物体O-GlcNAc糖链特异性标记和功能解析这一科学问题，构建了整套活细胞染色质糖蛋白标记的化学基因组学策略。实现了糖蛋白生物正交标记与高通量活性分析，组学水平揭示了染色质O-GlcNAc特征糖基化作为新的表观密码（糖密码）的重要功能，发现了多个肿瘤治疗新靶点。创制了特定O-GlcNAc糖基化的高效抑制剂分子，成功干预肿瘤异常O-GlcNAc糖基化，抑制多种类型肿瘤进展。研究工作在领域内形成鲜明特色，开辟了利用化学标记跨维度研究染色质糖密码功能的新途径，为糖生物学研究提供新范式和新策略。

发表高水平论文50余篇，包括中科院一区10篇，自然指数期刊3篇，主持国家自然科学基金等项目十余项，参与国家重大科技专项等。

代表性研究论文：

1. Liu, Yubo; Chen, Qiushi; Zhang, Nana; Zhang, Keren; Dou, Tongyi; Cao, Yu; Liu, Yimin; Li, Kun; Hao, Xinya; Xie, Xueqin; Li, Wenli; Ren, Yan*; Zhang, Jianing*; Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response, Nature Communications, 2020, 11, 5898. 

2. Liu, Yajie; Yu, Kairan; Kong, Xiaotian; Zhang, Keren; Wang, Lingyan; Zhang, Nana; Chen, Qiushi; Niu, Mingshan; Li, Wenli; Zhong, Xiaomin; Wu, Sijin*; Zhang Jianing*; Liu, Yubo*; FOXA1 O-GlcNAcylation-mediated transcriptional switch governs metastasis capacity in breast cancer. Science Advances, 2023, 9, eadg7112. 

3. Wang, Lingyan; Li, Guofang; Zhou, Ziyu; Ge, Chang; Chen, Qiushi; Liu, Yajie; Zhang, Nana; Zhang, Keren; Niu, Mingshan; Li, Wenli; Zhong, Xiaomin; Wu, Sijin*; Zhang Jianing*; Liu, Yubo*; Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263. Oncogene, 2023, 42, 2329-2346. 

4. Liu, Yangzhi; Yu, Kairan; Zhang, Keren; Niu, Mingshan; Chen, Qiushi; Liu, Yajie; Wang Lingyan; Zhang, Nana; Li, Wenli; Zhong, Xiaomin; Li, Guohui; Wu Sijin*; Zhang Jianing*; Liu, Yubo*; O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance. EMBO Reports, 2023, 24, e56458. 

5. Wu, Qiong; Zhang, Cheng; Zhang, Keren; Chen, Qiushi; Wu, Sijin; Huang, Huang; Huang, Tianmiao; Zhang, Nana; Wang, Xue; Li, Wenli; Liu, Yubo*; Zhang, Jianing*; ppGalNAc-T4-catalyzed O-Glycosylation of TGF-β type II receptor regulates breast cancer cells metastasis potential, Journal of Biological Chemistry, 2021, 296, 100119.

2009.9 -- 2014.12
开云平台首页       生物化工       博士

2005.9 -- 2009.7
开云平台首页       生物技术       学士