郭潇佳，副教授。2013年于四川大学获学士学位，2019年于中国科学院大连化学物理研究所获博士学位，并在中国科学院大连化学物理研究所从事博士后研究工作。主要从事酶工程和合成生物学研究，侧重蛋白质定向进化和微生物代谢工程等前瞻性研究方向。欢迎对酶工程、合成生物学、分子生物学等方向感兴趣的同学报考硕士和博士研究生，欢迎博士毕业生加入课题组开展博士后研究工作。

代表性论文：

1. Li Q, Guo XJ, Wang XY, Wang JT, Wan L, Xue HZ, Zhao ZK*. Creation of cytochrome P450 catalysis depending on a non-natural cofactor for fatty acid hydroxylation. J. Energy Chem. 2023, 79, 31-36.

2. Wang JT, Guo XJ*, Wan L, Liu YX, Xue HZ, Zhao ZK.* Engineering formaldehyde dehydrogenase from Pseudomonas putida to favor nicotinamide cytosine dinucleotide. ChemBioChem 2022, 23(7), e202100697.

3. Wang XY, Feng YB, Guo XJ, Wang Q, Ning SY, Li Q, Wang JT, Wang L, Zhao ZK*. Creating enzymes and self-sufficient cells for biosynthesis of the non-natural cofactor nicotinamide cytosine dinucleotide. Nat. Commun. 2021, 12(1), 2116.

4. Liu YX*, Guo XJ, Liu WJ, Wang JT, Zhao ZK. Structural insights into malic enzyme variants favoring an unnatural redox cofactor. ChemBioChem 2021, 22, 1765-1768.

5. Guo XJ, Liu YX, Wang Q, Wang XY, Li Q, Liu WJ, Zhao ZK*. Non-natural cofactor and formate-driven reductive carboxylation of pyruvate. Angew. Chem. Int. Ed. 2020, 59(8), 3143-3146.

6. Guo XJ, Wang XY, Liu YX, Li Q, Wang JT, Liu WJ*, Zhao ZK*. Structure-guided design of formate dehydrogenase for regeneration of a non-natural redox cofactor. Chem. Eur. J. 2020, 26(70), 16611-16615. 

7. Guo XJ, Feng YB, Wang XY, Liu YX, Liu WJ, Li Q, Wang JT, Xue S, Zhao ZK*. Characterization of the substrate scope of an alcohol dehydrogenase commonly used as methanol dehydrogenase. Bioorg. Med. Chem. Lett. 2019, 29(12), 1446-1449.

8. Guo XJ, Shen HW, Liu YX, Wang Q, Wang XY, Peng C, Liu WJ, Zhao ZK*. Enabling heterologous synthesis of lupulones in the yeast Saccharomyces cerevisiae. Appl. Biochem. Biotechnol. 2019, 188, 787-797.

9. Liu YX, Feng YB, Wang L, Guo XJ, Liu WJ, Li Q, Wang XY, Xue S*, Zhao ZK*. Structural insights into phosphite dehydrogenase variants favoring a non-natural redox cofactor. ACS Catal. 2019, 9, 1883-1887.

生物质转化研究室